学习经历

2001.2-2003.12，中国科大统计与金融系概率论与数理统计专业（导师：应志良教授、赵林城教授），获理学博士学位。

1997.9-2000.6，中国科大数学系应用数学专业（导师：赵林城教授），获理学硕士学位。

1993.9-1997.6，中国科大数学系计算数学及其应用软件专业，获理学学士学位。

工作经历

2018.6至今，中国科大统计与金融系，教授、博导。

2011.2-2018.5，复旦大学生物统计学研究所，研究员、博导。

2000.7-2011，中国科大统计与金融系，助教/讲师。

博士后研究

2009.1-2010.12，美国NIH国立癌症研究所（postdoctoral visiting fellow）

2006.8-2007.11，耶鲁大学医学院（postdoctoral associate）

2004.3-2005.4，乔治华盛顿大学统计系（postdoctoral scientist）

主要研究方向

医学大数据分析、遗传统计。

研究成果

在Biometrika、Biometrics、Bioinformatics、Annals of Applied Statistics、Statistics in Medicine、Statistica Sinica、Biostatistics、 Computational Statistics & Data Analysis 、 Proceedings of the National Academy of Sciences（PNAS）、Human Molecular Genetics、NeurIPS等国内外统计学期刊/会议上发表论文90多篇，获得逾千次引用，其中大部分为他引（谷歌学术检索）。

部分国家级研究项目

1. 基于核心家庭全基因组关联研究的亲源效应分析，国家自然科学基金面上项目，12171451，51万，2022.1.1-2025.12.31，主持人

2. 平台供应链的统计学习方法研究，国家自然科学基金重大项目（课题二），72091212，248万，2021.1-2025.12，专题负责人
   

3. 基于新一代高通量测序数据的若干统计方法学研究，国家自然科学基金面上项目，11771096，48万，2018.1.1-2021.12.31，主持人

4. 基于新一代测序数据的统计遗传学新理论、方法与应用，973项目（课题五），2012CB316505, 约900万，2012.1.1-2016.8.31，课题骨干

5. 全基因组DNA甲基化研究中的统计学方法，国家自然科学基金面上项目，11371101, 50万，2014.1.1-2017.12.31，主持人

6. 人类基因关联分析的若干问题，国家自然科学基金青年项目，10701067, 15万，2008.1.1-2010.12.31，主持人

研究生培养

截至到2024年已经培养了7名博士和19名硕士。

研究生招生

欢迎对研究有热情、具有扎实数理基础的本科生报考本人的博士研究生。

部分论文列表（更多论文列表见https://www.researchgate.net/profile/Hong-Zhang-21或https://scholar.google.com/citations?user=bjHB50UAAAAJ&hl=en）：

26. Zhang H#, Mukherjee B, Arthur V, Hu G, Hochner H, Chen J# (2020). An Efficient and Computationally Robust Statistical Method for Analyzing Case-Control Mother-Offspring Pair Genetic Association Studies. Annals of Applied Statistics 14: 560-584.

25. Ji Y, Yu C, Zhang H# (2020). contamDE-lm: Linear model based differential gene expression analysis using next-generation RNA-seq data from contaminated tumor samples. Bioinformatics 36: 2492-2499.

24. Yu C, Chen F, Jiang J, Zhang H#, Zhou M# (2019). Screening key genes and signaling pathways in colorectal cancer by integrated bioinformatics analysis. Molecular Medicine Reports 20: 1259-1269.

23. Lyu T, Ying Z, Zhang H# (2019). A new semiparametric transformation approach to disease diagnosis with multiple biomarkers. Statistics in Medicine 38:1386-1398.

22. Zhang H, Chatterjee N, Rader D, Chen J (2018). Adjustment of non-confounding covariates in case-control genetic association studies. Annals of Applied Statistics 12(1):200-221.

21. Wang C, Shen Q, Du L, Xu J, Zhang H# (2018). armDNA: A functional beta model for detecting age-related genomewide DNA methylation marks. Statistical Methods in Medical Research 27: 2627-2640.

22. Zhou B, Wen S, Wang L, Jin L, Li H, Zhang H# (2017). AntCaller: An accurate variant caller incorporating ancient DNA damage. Molecular Genetics and Genomics 292(6):1419-1430.

19. Kang G, Du L, Zhang H# (2016). multiDE: a dimension reduced model based statistical method for differential expression analysis using RNA-sequencing data with multiple treatment conditions. BMC Bioinformatics 17: 248.

18. Shen Q, Hu J, Jiang N, Hu X, Luo Z, Zhang H# (2016). contamDE: Difierential expression analysis of RNA-seq data for contaminated tumor samples. Bioinformatics 32(5): 705-712.

17. Hu J, Li T, Xiu Z, Zhang H# (2015). MAFsnp: A Multi-sample Accurate and Flexible SNP Caller Using Next-generation Sequencing Data. PLoS ONE 10(8): e0135332. 

16. Zhang H#, Xu J, Jiang N, Hu X, Luo Z (2015). PLNseq: a multivariate Poisson lognormal distribution for high-throughput matched RNA-sequencing read count data. Statistics in Medicine 34: 1577-1589.

15. Zhang H, Qin J, Landi M, Caporaso N, Yu K (2013). A copula-model based semiparametric interaction test under the case-control design. Statistica Sinica. 23: 1505-1521.

14. Zhang H, Zeng D, Olschwang S, Yu K (2013). Semiparametric inference on the penetrances of rare genetic mutations based on a case-family design. Journal of Statistical Planning and Inference. 143: 368-377.

13. Zhang H, Wacholder S, Qin J, Hildesheim A, Yu K (2011). Improved genetic association tests for an ordinal outcome representing the disease progression process. Genetic Epidemiology 35:499-505.

12. Zhang H, Ahn J, Yu K (2011). Comparing statistical methods for removing seasonal variation from vitamin D measurements in case-control studies. Statistics and Its Interface. 4:85-93.

11. Li T, Li Z, Ying Z, Zhang H#. (2010). Influence of population stratification on population based marker-disease association analysis. Annals of Human Genetics. 74:351-360.

10. Zhang H, Olschwang S, Yu K. (2010). Statistical inference on the penetrances of rare genetic mutations based on a case-family design. Biostatistics 11:519-532.

9. Wu C*, Zhang H*, Liu X, DeWan A, Dubrow R, Ying Z, Yang Y, Hoh J (2009). Detecting essential and removable interactions in genome-wide association studies. Statistics and Its Interface 2:161-170.

8. Zhang H, Chen H, Li Z. (2009). Large sample interval mapping method for genetic trait loci infinite regression mixture models. Journal of Statistical Planning and Inference 139:764-779.

7. Yan T, Yang Y, Cheng X, DeAngelis MM, Hoh J, Zhang H# (2009). Genotypic association analysis using discordant-relative-pairs. Annals of Human Genetics 73:84-94.

6. Francis P*, Zhang H*, DeWan A, Hoh J, Klein M (2008). Joint eects of polymorphisms in the HTRA1, LOC387715/ARMS2, and CFH genes on AMD in a Caucasian population. Molecular Vision 14:1395-1400.

5. Zhang H, Morrison MA, DeWan A, Adams S, Andreoli M, Huynh N, Regan M, Brown A, Miller JW, Kim IK, Hoh J, DeAngelis MM (2008). The NEI/NCBI dbGAP database: Genotypes and haplotypes that may specifically predispose to risk of neovascular age-related macular degeneration. BMC Medical Genetics 9:51.

4. Chen K*, Ying Z*, Zhang H*, Zhao L* (2008). Analysis of least absolute deviation. Biometrika 95(1):107-122.

3. Zhang H, Chen H, Li Z. (2008). An explicit representation of the limit of the LRT for interval mapping of quantitative trait loci. Statistics and Probability Letters 78:207-213.

2 Zhang Han, Zhang Hong#, Li Zhaohai, Zheng Gang (2007). Statistical methods for haplotype-based matched case-control association studies. Genetic Epidemiology. 31(4):316-326.

1. Zhang H, Zheng G, Li Z (2006). Statistical analysis for haplotype-based matched case-control studies. Biometrics 62:1124-1131.